Double-stranded deoxyribonucleic acid binds to HLA class II molecules and inhibits HLA class II-mediated antigen presentation
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ULCERATIVE COLITIS AND HLA CLASS II PHENOTYPING IN IRAN
Ulcerative colitis (UC) is a nonspecific acute and chronic inflammatory bowel disease that diffusely involves the colonic mucosa. The etiology of UC has not yet been elucidated fully. However, many studies have found that immunologic disorders may play a role in the pathogenesis of UC. In addition, due to an increased frequency of UC in families, especially an increased monozygotic compared...
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Background: Pulmonary tuberculosis (PT) is one of the endemic diseases in Iraq, and among the suggested predisposing factors are alleles of the human leukocyte antigen (HLA) system. We sought to investigate the association between HLA-class I (A and B) and -class II (DR and DQ) alleles in a sample of PT Iraqi patients.Methods: lymphocytes of 105 PT patients and 40 controls were phenotyped for H...
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Background: The high polymorphism in the human leukocyte antigen (HLA) genes can be used as an identity of individuals to compare with other populations. This extreme polymorphism in the HLA system is accountable for the differences in alleles and haplotypes among ethnic groups, populations, and the inhabitants of many regions. Objective: To define the frequency of HLA alleles and haplotypes am...
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Khoury, S. J., Hancock, W. W. and Weiner, H. L. 31 (1992) J. Exp. Med. 176, 1355-1364 Ku, G., Kronenberg, M., Peacock, D. J., Tempest, 32 P., Banquerigo, M. L., Braun, B. S., Reeve, J. R. and Brahn, E. (1993) Eur. J. Immunol. 23, 591-599 Ye, X. J., Terato, K., Myers, L., Brand, D. D., Kang, A. and Cremer, M. A. (1994) Arthritis 3653-3659 V., Holmdahl, R. and Bansal, S. (1996) Clin. Exp. Immunol...
متن کاملمطالعه وابستگی اللهای ژنهای HLA-class II ((HLA-DRB/DQA1/DQB1 و سرطان پستان
Background: Based on the reports, high frequency of special alleles of HLA class II genes might be associated with susceptibility to or protective from a particular cancer. These alleles might vary depending on the geographical region. Here we investigate the association between alleles of HLA class II genes and breast cancer in Iranian women.Methods: 100 patients with pathologically proved bre...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 1998
ISSN: 0014-2980,1521-4141
DOI: 10.1002/(sici)1521-4141(199812)28:12<3968::aid-immu3968>3.0.co;2-6